Around mid-1990s, a group of scientists tested the substance intended for the myocardium treatment called Sildenafil. They reasonably assumed that improved blood flow would also strengthen sexual abilities. However, the new drug didn’t take any intended effect on the activity of the cardiovascular system at all. But it showed an extremely good curative effect of a different kind. Almost all men experienced increased sexual reaction after taking Sildenafil. Even persons of age noted that the erection and sexual desire came back again. A few years later, Viagra was launched.
Silagra by Cipla Inc. is a modern tool for improving potency, created to heal erectile dysfunction of any degree. In fact, it is a popular analogue of the famous Viagra. As opposed to Viagra the medication described in this article was created by Indian pharmacological company specifically for the domestic market. Consumers in India welcomed the preparation with excitement. It was obvious that the invented medication fully corresponded to the needs of the Indians. It was inexpensive, but efficient. Its popularity in India became so high, that it was decided to develop a product for the foreign market. Now this wonderful product is available to us. It has helped millions of men to retrieve comfort and self-confidence. There is an opinion among its users, that among a huge number of Viagra replicas, this one has the most powerful and lasting effect.
The given preparation is made in the form of an oval biconvex tablet with light blue glaze, with a line in the center on one side, and flat on the other.
The international name of active component is Sildenafil.
The pill is produced in a dosage of fifty and one hundred milligrams. The tablet also contains some auxiliary substances:
- magnesium stearate,
- silicone dioxide,
- hydroxypropyl ethylcellulose,
- titanium dioxide,
- triacetin and indigo glaze;
The given drug is prescribed for curing of erectile dysfunction in males. Recent clinical studies have demonstrated an extremely high efficiency of the tablets for curing of erectile dysfunction caused by: stress, depression, smoking, alcohol abuse, blood circulation disorders, sugar addiction and age.
Sildenafil is well-known among specialists as a selective inhibitor of cGMP-specific phosphodiesterase type five (PDE-5). I guess we do not have to tell tou that mechanism is a wide-spread solution. This chemical compound ensures the cGMP disintegration in the cavernous body, which is the main part of a penis. Tablets exert a peripheral influence on the erection. Although sildenafil does not produce a direct relaxation of the cavernous body, it significantly improves the relaxation action of another thing, which is nitric oxide. It is not surprising that the depression of PDE 5 under the influence of sildenafil leads to a significant increase of the cGMP level in the cavernous body. Please do not forget, that for the successful development of a favorable pharmacological effect, adequate sexual stimulation is necessary.
To detect erectile dysfunctions, one should determine their causes and choose the most adequate treatment for each individual case, the doctor should get an expand medical history and conduct a careful examination of the patient, taking into account all his other problems and issues, even if they seem completely unrelated to the main subject of our article.
Although the drug is well tolerated, however, like Viagra etc., it can be the cause of some unpleasant by-effects. During clinical trials around 3% of men had: headache, constipation or diarrhea, nasal congestion, digestive system disorders, backache and deterioration of vision.
In most cases, these were short-term manifestations. Men with individual intolerance to Sildenafil can experience various allergic hypersensitivity. Among the contraindications for use are sensitivity to the components of the drug; use together with nitrates in any form; bad renal failure, or a recent stroke. It is quite understandable that this is not the only medication that shouldn’t be practiced in case of such severe disorders.
In addition, sexual activity produces a certain risk if one has diseases of the cardiovascular system. In this regard, before the mediction of erectile dysfunction starts, it is worth to conduct a cardiac examination. After introduction of the drug, serious cardiovascular abnormalities were announced that included angina pectoris, gastric arrhythmias, myocardial infarction, hemorrhagic stroke, transient ischemia, arterial hypertension or hypotension. In general, those developed during sexual activity or immediately after it. In most cases, and which is proved by official statisitcal evidence, there were revealed hazards for the development of cardiovascular diseases.
It is also important to notice that all drugs intended for curing of erectile dysfunction must be prescribed with caution to those who suffer from anatomical deformation of the musculine organ, such as priangulation or cavernous fibrosis. It is also true for men with diseases that contribute to the development of priapism, take for example drepanocytemia, leucosis and also multiple myeloma. Unfortunately, we have no evidence of the safety of the medicine for peptic ulcer. In this regard, the drug can be prescribed to people suffering from this pathology also with special caution.
It ought to be noted that there is no specific information on the safety concerning those who suffer from pigment retinitis or PDEE retinal disorders.
The drug is not intended for application by people under 18, females, and people for whom sexual activity is undesirable. You can raise the dose to 100 or lower it to 25 milligrams, taking into account the efficiency and tolerability for the given patient. The highest dose can not exceed 100 milligrams per day. For elderly people and patients with violent renal insufficiency or a violation of liver function, the initial dosage should not exceed 25 milligrams. Taking into account the efficiency level and tolerability, the dose can be lowered.
That’s true that the drug is quickly absorbed right after ingestion. Thus, the concentration of the substance after its administration reaches a maximum value in the plasma within an average of sixty minutes. Absolute concentration at intake makes at the average 40-50%. When taking the substance in combination with some fats, the absorption rate decreases, the period of reaching the maximum concentration increases by one hour, and the highest level of concentration in the blood plasma is reduced at an average by 30-40%.
In case of an overdose intensification in side effects is normally observed. In such cases, symptomatic therapy is recommended. Dialysis is ineffective.
Since dizziness and some visual impairment were noticed during intake of sildenafil, do not drive car or work with potentially dangerous mechanisms until the individual reactions to the pharmaceutical product is elucidated.
The effectiveness and safety of its use mixed with other agents intended for the curing of erectile dysfunction have not yet been studied, so it should be kept in mind that the simultaneous use is also not advised, the more so that there are some unsupported scientific evidence and reports that it might bring overstimulation. Well, the best is the enemy of the good. The application of the active substance in question together ritonavir, a highly specific inhibitor of P-450, is also not recommended. Simultaneous intake of these inhibitors with equal concentration leads to about a 20% rise of the concentration of sildenafil in blood plasma. Cimetidine, a nonspecific CYP3A4 inhibitor, while taking with the described drug caused an increase in the concentration of the active substance in blood plasma by 55%. Recently an analysis of the results of the pharmacokinetic clinical trial was held, which demonstrated a decrease in the clearance of sildenafil with simultaneous use of some CYP3A4 inhibitors, however the incidence of by-effects did not enhance, which makes them safe to use in the described combination. However, we have to warn you that using every combination you have also to study the instructions for use of the second medication or product that will co-applied.
It is obvious that a single intake of an antacid cannot affect the bioavailability of the medicine.
The pharmaceutical product in a dose of twenty to fifty milligram did not cause an increase in the time of bleeding if combined with acetylsalicylic acid in a dose less than 150 milligrams. It also did not increase the antihypertensive effect of alcohol in healthy people with a maximum blood alcohol level of 80 mg/ dl. The pill elevates the hypotensive effect of nitrates, and therefore their simultaneous use is dangerous, at least if you are a reasonable person.
Store the drug in its original packaging in a dry place at temperatures up to 30 C. Keep out of the reach of children. Shelf life is 3 years.
The following drugs are the most popular analogues of the tablets, discussed in this article:
We think that the effectiveness of the tablet can be best demonstrated by the reviews of men who take it.
Alexander (54): I recommend this medicine to all men who have encountered the problem of erectile dysfunction. It was this drug that gave me the opportunity to return to normal and healthy lifestyle, even despite a heart attack.
Ireneus (41): Some believe that in case of poor erection induced by spirits, the drug will help to be fully armed, regardless of the amount of alcohol. Gimme a break! Never use Silagra with alcohol. It can produce unpredictable effects!
Oliver (46): The drug starts working only when you are in proximity to a woman, and only then you will turn into a macho! You should try it at least once. The price of one tablet is not high and it is worth paying, as opposed to some analogues.
Gregory (38): It is very important that the drug is not addictive, so there is no problem to drop it. As it turned out, in my case, sexual dysfunction was more psychological, I could not psychologically tune in for a good result. A miracle cure helped me to regain confidence in myself!
George (49): Same as with prescriptions of all drugs for man’s strength, it is not recommended taking the pill more than once a day, well, I believe that at our age (around 45) it should not be taken more than once in two days. The effect of the drug surprised me, and I reduced the dose to 1/4 tablet. I hope there will be fewer side effects now. Although the effect of the drug is limited to 5 hours, it is enough for me.